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AML Leukemia and Benzene News

Acute Myelogenous Leukemia News

Gene therapy studies suspended after death
Fischer has treated 17 patients, and virtually all have shown major improvement--if not a cure. But two years ago, Fischer said that two of the patients developed leukemia, presumably as a result of the treatment.

Training with a purpose
Leatherman is a runner who competes in races and marathons in the area. Using his ability, he plans to run in a Triathlon to raise funds for the Leukemia Society. His motivation is a three-year-old boy named Isaac who was diagnosed in 2001 with Acute Myelogenous Leukemia.

NCCN Releases Acute Myeloid Leukemia and Chronic Myelogenous Leukemia Chapters of the NCCN Drugs & Biologics Compendium
The NCCN Drugs & Biologics Compendium outlines the appropriate uses of drugs and biologics in the care of cancer patients, as derived from the NCCN Clinical Practice Guidelines in Oncology(TM) -- recognized and applied nationally as the standard for clinical policy in oncology.

Revlimid™ Effective for Low-Risk Myelodysplastic Syndromes
MDS is a disease in which the cells in a person's bone marrow are not functioning normally. The bone marrow (and circulating blood) contains early blood-forming cells called stem cells, which grow and mature into the 3 blood cell types: white blood cells, which protect the body from infection; red blood cells, which carry oxygen to the tissues; and platelets, which help the blood to clot. In the case of MDS, not enough normal blood cells are being produced and/or the blood cells die prematurely. This condition is sometimes referred to as a pre-leukemia or "smoldering" leukemia because it often develops into acute myeloid leukemia, an aggressive type of cancer.

Protein that promotes survival of stem cells might be key to poor leukemia prognosis
Finding that Mcl-1 blocks cell suicide in hematopoietic stem cells also suggests that interfering with this protein might improve leukemia treatment

Plant derivative attacks the roots of leukemia
Parthenolide is the first single agent known to act on myeloid leukemia at the stem-cell level, which is significant because current cancer treatments do not strike deep enough to kill mutant cells where the malignancy is born. In other words, even the most progressive leukemia treatment, a relatively new drug called Gleevec, is effective only to a degree.

Vaccine may Improve Leukemia Treatment
A vaccine that stimulates immune response could boost the effectiveness of conventional treatment for patients with chronic myeloid leukemia, according to a new study.

Genome-wide mouse study yields link to human leukemia
In comparing the mice in the pre-leukemic stage and those with ALL with normal mice, researchers found that methylation, a chemical process that adds methyl molecules to DNA, silenced a number of genes – but only in the mice with full-blown ALL. Further tests revealed that the methylation pattern in the mice with leukemia is strikingly similar to the pattern of methylation in human leukemia.

Teva takes option to commercialize Gamida-Cell's Stem-Ex
Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA; TASE: TEVA) and Gamida-Cell Ltd. announced today that Teva has exercised the option to enter into a joint venture with Gamida-Cell Ltd. The two companies will develop and commercialize Gamida-Cell's StemEx for the treatment of leukemia and lymphoma.

New Drug Helps Children Fight Leukemia
For the first time in more than a decade, there's a new drug to help children fight leukemia, Local 2 reported Tuesday. The Food and Drug Administration recently approved clolar for children who did not respond to traditional therapies.

Xcyte Therapies, Inc. Announces Publication of Paper Describing Mechanism of Action of Xcellerated T Cells
Xcyte Therapies, Inc. ("Xcyte") (Nasdaq:XCYT) announced today the publication of a scientific paper describing the mechanism of action of its lead product, Xcellerated T Cells, in chronic lymphocytic leukemia (CLL).

Aranesp® Effective in Low-Intermediate Risk MDS
Myelodysplastic syndromes (MDS) are a group of diseases involving the bone marrow resulting in inadequate production of red blood cells, white blood cells and platelets. This group of diseases ultimately progresses to bone marrow failure or acute leukemia.

Callisto Pharmaceuticals Announces 2005 Corporate Objectives and Update on Drug Development Pipeline
Callisto is a biopharmaceutical company focused on the development of drugs to treat cancer and osteolytic bone disease. Callisto recently in-licensed Annamycin, a drug to treat leukemia, based on the drug's novel therapeutic profile, including activity against resistant diseases and significantly reduced toxicity

Scripps can make an astronomical difference
Is there suddenly a leukemia epidemic and people are mobilizing? Is awareness of lymphoma reaching new heights? No, although the Leukemia & Lymphoma Society is certainly a worthy cause. It aims to find a cure for those dreaded diseases as well as Hodgkin's and myeloma. It helps patients who are stricken with them.

Leukemia drug breakthrough study in New England Journal of Medicine
Alan List, M.D., leader of the Hematologic Malignancies Program at the H. Lee Moffitt Cancer Center & Research Institute, recently conducted a phase I/II trial of the experimental drug Revlimid showing promise as an innovative way to treat patients with myelodysplastic syndrome (MDS), a form of pre-leukemia.

Women fight leukemia with poses
Team in Training is the world's largest endurance sports training program. The program trains participants for a marathon, triathlon, or century ride while they raise money for the Leukemia and Lymphoma Society. The society is dedicated to curing leukemia, lymphoma, Hodgkin's disease and myeloma.

Losing weight can cut cancer risk
Overweight and obese women also face greater odds of developing acute myelogenous leukemia (AML), according to the University of Minnesota Cancer Center study cited in the December issue of the Environmental Nutrition newsletter.

Cord Blood Transplant Recipients Call On House Legislators to Pass H.R. 596
Cord blood stem cells, obtained from the placenta and umbilical cord and donated by the mother, have been successfully used to treat such malignant and genetic diseases. Cord blood is a non-controversial source of stem cells, which -- unlike bone marrow -- can be collected without risk of any kind to donors and stored frozen, in fully usable conditions, for many years. The great advantage of cord blood transplantation is that it does not require as exacting a tissue type match as donated bone marrow does. Thus, patients with uncommon tissue types, as is the case of many ethnic minority individuals, can find appropriate matches.

Rare but deadly side effects
My husband took Lamisil to treat toenail fungus. The fine print for this prescription drug noted that it might cause neutropenia. For my husband, it did. This led to MDS (myelodysplastic syndrome, which was followed by AML (acute myeloid leukemia) and his subsequent death

Prayer Power Unleashed - Commentary on the News
He said, that no one with a full blown case of Leukemia(AML), [as my mom], has been discharged within three weeks of treatment. The Doctor is still in a shock.

Drug Helps Patients at High Risk for Leukemia
A drug gentle enough for patients in their 70s or 80s is showing promise for the treatment of myelodysplastic syndrome (MDS), a pre-leukemic disorder that can progress to acute myelogenous leukemia (AML),

Dacogen(TM) NDA Accepted for Filing by FDA
SuperGen, Inc. and MGI PHARMA, INC. today announced that the New Drug Application (NDA) for Dacogen(TM) (decitabine) for injection was accepted for filing by the United States Food and Drug Administration (FDA).

Community, friends coming to aid of leukemia victim
Mama was right. What goes around does come around. The proof of that is particularly evident in the case of a local special education teacher who is fighting her second battle with acute myelogenous leukemia at Vanderbilt University Medical Center.

Arsenic Trioxide and Pixantrone Highlighted in 42 Abstracts and Presentations at The American Society of Hematology Meeting
Data on arsenic trioxide will be presented in the treatment of leukemia, multiple myeloma and myelodysplasia. Two phase II studies will provide updated information on the potential clinical activity of pixantrone in non-Hodgkin's lymphoma.

Enrolling in a Study? Most Don't Ask Key Questions
A majority of people who enter clinical trials do so without knowing what questions to ask, and many don't understand the risks of study participation, a new survey confirms.

Arsenic Trioxide & MDS: Leukemia
Arsenic trioxide in patients with myelodysplastic syndromes (MDS): Preliminary results of a phase II clinical study.

Fed scrutiny over Cell Therapeutics' marketing tactics
To branch into bigger markets with thousands of patients, the company has tested Trisenox against a deadly bone-marrow cancer, multiple myeloma and a pre-leukemia syndrome called MDS

Bone Marrow drive Dec. 1 for Pax engineering tech
Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets.

Heartfelt response to area girl's battle with cancer
Jackie, 17, was diagnosed with myelodysplastic syndrome (MDS) in February. The disease, an inability to produce healthy blood cells, which often leads to acute leukemia, is very rare and fatal without proper treatment.

CEPSA invests in new refining and petrochemical projects
The new facility will produce 220,000 tons per year of benzene and 75 tons per day of hydrogen, in addition to other products.

Psychology department to survey community about motorboat ban
Benzene, a carcinogenic substance, is a pollutant found in the atmosphere and in gasoline, Legg said. The benzene level in drinking water cannot exceed five parts per billion, according to the EPA Web site.

R&D Trends To Set The Future Leukemia Marketplace
To enable people to update their knowledge status at the same time receive a basic foundation, this report "Competition on the Future Leukemia Markets" describes and analyzes the latest year of progress in four different market segments; CLL, CML ALL and AML.

High-Voltage Cable Pylons 'double child cancer risk'
Children living under high-voltage power lines could run double the risk of getting cancer, new research reportedly suggests. Those living within 100 metres of the cables are more likely to suffer from leukaemia, the study indicates.

Novel compound, VX-322, targets key mechanisms implicated in leukemia
Flt-3 inhibition has attracted significant attention among cancer researchers as a highly targeted approach to the treatment of certain leukemias as well as other hematological malignancies and solid tumors. Flt-3 is abnormally activated or upregulated in a wide range of leukemias, including more than 70% to 100% of patients with acute myelogenous leukemia (AML).

Herbal remedy cuts effectiveness of anticancer pill
We found that St. John's Wort may significantly reduce the effect of Gleevec® by lowering blood levels to the point where patients may fail therapy if they take both together

Researchers have documented a novel form of resistance in leukemia cells to an anti-cancer drug
Researchers at Virginia Commonwealth University’s Massey Cancer Center have documented a novel form of resistance in leukemia cells to an anti-cancer drug, which could help scientists develop new strategies for treating the disease.

Obesity Linked to Acute Leukemia
A new study shows that older overweight women significantly increase their risk of acute leukemia. Acute myelogenous leukemia (AML) is the most common form of leukemia in adults and the rates of this cancer are growing among older adults. It is not an inherited disease but the result of genetic damage to developing cells in the bone marrow.

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